School of Biochemistry and Immunology
Dr Amir Khan
Email: amir.khan AT tcd.ie
Dr. Amir Khan’s group are dedicated to exploring the molecular basis for biological processes in living cells. The main technique employed in their laboratory is X-ray diffraction, which allows visualization of the three-dimensional architecture of macromolecules. There are two main projects in their laboratory. The first is a structural study of Rabs with their effector proteins, and the mechanism by which these complexes regulate vesicle trafficking. A second major initiative involves structural studies of Toll receptor signalling pathways, which are essential for innate immunity against bacteria and viruses. The overall research goal is to provide insight into the specificity of signaling complexes, and how they lead to changes in cellular activity. To address these problems, the lab is fully equipped for protein expression, purification, crystallization and structure determination.
Dr. Amir Khan is currently a lecturer in the School of Biochemistry and Immunology in Trinity College Dublin. His group was established in 2004 with support from the Health Education Authority (through their PRTLI3 initiative), as well as a grant from Science Foundation Ireland.